diff --git a/boards/limifrog-v1/include/periph_conf.h b/boards/limifrog-v1/include/periph_conf.h
index 020caa4abe8987054a6ccc16e89d636cf301fbb7..edd475914488e4e37a858b2b05f618c5ad390fff 100644
--- a/boards/limifrog-v1/include/periph_conf.h
+++ b/boards/limifrog-v1/include/periph_conf.h
@@ -131,45 +131,30 @@ static const timer_conf_t timer_config[] = {
 
 /**
  * @name I2C configuration
-  * @{
+ * @{
  */
 #define I2C_NUMOF           (2U)
 #define I2C_0_EN            1
 #define I2C_1_EN            1
+
+static const i2c_conf_t i2c_cfg[] = {
+    /* Device, SCL-, SDA-Pin, AF, Event-, Error-IRQ, Clock enable */
+    {I2C1, GPIO_PIN(PORT_B, 8), GPIO_PIN(PORT_B, 9), 4,
+     I2C1_EV_IRQn, I2C1_ER_IRQn, RCC_APB1ENR_I2C1EN},
+    {I2C2, GPIO_PIN(PORT_B, 10), GPIO_PIN(PORT_B, 11), 4,
+     I2C2_EV_IRQn, I2C2_ER_IRQn, RCC_APB1ENR_I2C2EN},
+};
+
 #define I2C_IRQ_PRIO        1
 #define I2C_APBCLK          (36000000U)
 
 /* I2C 0 device configuration */
-#define I2C_0_DEV           I2C1
-#define I2C_0_CLKEN()       (RCC->APB1ENR |= RCC_APB1ENR_I2C1EN)
-#define I2C_0_CLKDIS()      (RCC->APB1ENR &= ~(RCC_APB1ENR_I2C1EN))
-#define I2C_0_EVT_IRQ       I2C1_EV_IRQn
 #define I2C_0_EVT_ISR       isr_i2c1_ev
-#define I2C_0_ERR_IRQ       I2C1_ER_IRQn
 #define I2C_0_ERR_ISR       isr_i2c1_er
-/* I2C 0 pin configuration */
-#define I2C_0_PORT_CLKEN()  (RCC->AHBENR |= RCC_AHBENR_GPIOBEN)
-#define I2C_0_PORT          GPIOB
-#define I2C_0_SCL_PIN       8
-#define I2C_0_SCL_AF        4
-#define I2C_0_SDA_PIN       9
-#define I2C_0_SDA_AF        4
-
-/* I2C 1 device configuration */
-#define I2C_1_DEV           I2C2         /* ST VL6180X, ST LSM6DS3, ST LIS3MDL, ST SLPS25H */
-#define I2C_1_CLKEN()       (RCC->APB1ENR |= RCC_APB1ENR_I2C2EN)
-#define I2C_1_CLKDIS()      (RCC->APB1ENR &= ~(RCC_APB1ENR_I2C2EN))
-#define I2C_1_EVT_IRQ       I2C2_EV_IRQn
+
+/* I2C 1 device configuration [ST VL6180X, ST LSM6DS3, ST LIS3MDL, ST SLPS25H]*/
 #define I2C_1_EVT_ISR       isr_i2c2_ev
-#define I2C_1_ERR_IRQ       I2C2_ER_IRQn
 #define I2C_1_ERR_ISR       isr_i2c2_er
-/* I2C 1 pin configuration */
-#define I2C_1_PORT_CLKEN()  (RCC->AHBENR |= RCC_AHBENR_GPIOBEN)
-#define I2C_1_PORT          GPIOB
-#define I2C_1_SCL_PIN       10
-#define I2C_1_SCL_AF        4
-#define I2C_1_SDA_PIN       11
-#define I2C_1_SDA_AF        4
 /** @} */
 
 #ifdef __cplusplus
diff --git a/boards/nucleo-l1/include/periph_conf.h b/boards/nucleo-l1/include/periph_conf.h
index 833a1c95d0025b142f3b85f0f4cd95cb6a2a9f71..be03bd8059d4e2f2d49f9c8f30967951f550b596 100644
--- a/boards/nucleo-l1/include/periph_conf.h
+++ b/boards/nucleo-l1/include/periph_conf.h
@@ -236,28 +236,30 @@ static const timer_conf_t timer_config[] = {
 
 /**
  * @name I2C configuration
-  * @{
+ * @{
  */
-#define I2C_NUMOF           (1U)
+#define I2C_NUMOF           (2U)
 #define I2C_0_EN            1
+#define I2C_1_EN            1
+
+static const i2c_conf_t i2c_cfg[] = {
+    /* Device, SCL-, SDA-Pin, AF, Event-, Error-IRQ, Clock enable */
+    {I2C1, GPIO_PIN(PORT_B, 8), GPIO_PIN(PORT_B, 9), 4,
+     I2C1_EV_IRQn, I2C1_ER_IRQn, RCC_APB1ENR_I2C1EN},
+    {I2C2, GPIO_PIN(PORT_B, 10), GPIO_PIN(PORT_B, 11), 4,
+     I2C2_EV_IRQn, I2C2_ER_IRQn, RCC_APB1ENR_I2C2EN},
+};
+
 #define I2C_IRQ_PRIO        1
 #define I2C_APBCLK          (36000000U)
 
 /* I2C 0 device configuration */
-#define I2C_0_DEV           I2C1
-#define I2C_0_CLKEN()       (RCC->APB1ENR |= RCC_APB1ENR_I2C1EN)
-#define I2C_0_CLKDIS()      (RCC->APB1ENR &= ~(RCC_APB1ENR_I2C1EN))
-#define I2C_0_EVT_IRQ       I2C1_EV_IRQn
 #define I2C_0_EVT_ISR       isr_i2c1_ev
-#define I2C_0_ERR_IRQ       I2C1_ER_IRQn
 #define I2C_0_ERR_ISR       isr_i2c1_er
-/* I2C 0 pin configuration */
-#define I2C_0_PORT_CLKEN()  (RCC->AHBENR |= RCC_AHBENR_GPIOBEN)
-#define I2C_0_PORT          GPIOB
-#define I2C_0_SCL_PIN       8
-#define I2C_0_SCL_AF        4
-#define I2C_0_SDA_PIN       9
-#define I2C_0_SDA_AF        4
+
+/* I2C 1 device configuration */
+#define I2C_1_EVT_ISR       isr_i2c2_ev
+#define I2C_1_ERR_ISR       isr_i2c2_er
 /** @} */
 
 #ifdef __cplusplus
diff --git a/cpu/stm32l1/include/periph_cpu.h b/cpu/stm32l1/include/periph_cpu.h
index a20ef4586e4156ce5b5553ef79f06a541467e4d0..57bbafc17f857c91347a3d9b30cf30f632052f51 100644
--- a/cpu/stm32l1/include/periph_cpu.h
+++ b/cpu/stm32l1/include/periph_cpu.h
@@ -100,7 +100,7 @@ typedef struct {
 } timer_conf_t;
 
 /**
- * @brief declare needed generic SPI functions
+ * @brief   declare needed generic SPI functions
  * @{
  */
 #define PERIPH_SPI_NEEDS_TRANSFER_BYTES
@@ -108,6 +108,19 @@ typedef struct {
 #define PERIPH_SPI_NEEDS_TRANSFER_REGS
 /** @} */
 
+/**
+ * @brief   I2C device configuration
+ */
+typedef struct {
+    I2C_TypeDef *dev;       /**< Pointer to the used I2C device */
+    gpio_t scl_pin;         /**< Pin used for SCL */
+    gpio_t sda_pin;         /**< Pin used for SDA */
+    uint8_t af_scl_sda;     /**< SCL or SDA AF */
+    uint8_t ev_irqn;        /**< I2C device Event Interrupt */
+    uint8_t er_irqn;        /**< I2C device Error Interrupt */
+    uint32_t clk_en;        /**< Clock enable register */
+} i2c_conf_t;
+
 #ifdef __cplusplus
 }
 #endif
diff --git a/cpu/stm32l1/periph/i2c.c b/cpu/stm32l1/periph/i2c.c
index a3afd4e0c15c6c4fa8309531c097b85527c31475..0d790b9ee8381a6ca15cf06d11b2c615a273df25 100644
--- a/cpu/stm32l1/periph/i2c.c
+++ b/cpu/stm32l1/periph/i2c.c
@@ -34,13 +34,10 @@
 #define ENABLE_DEBUG    (0)
 #include "debug.h"
 
-/* guard file in case no I2C device is defined */
-#if I2C_NUMOF
-
 /* static function definitions */
 static void _i2c_init(I2C_TypeDef *i2c, int ccr);
 static void _toggle_pins(GPIO_TypeDef *port, int pin_scl, int pin_sda);
-static void _pin_config(GPIO_TypeDef *port, int pin_scl, int pin_sda);
+static void _pin_config(i2c_t dev, GPIO_TypeDef *port, int pin_scl, int pin_sda);
 static void _start(I2C_TypeDef *dev, uint8_t address, uint8_t rw_flag);
 static inline void _clear_addr(I2C_TypeDef *dev);
 static inline void _write(I2C_TypeDef *dev, char *data, int length);
@@ -57,18 +54,16 @@ static mutex_t locks[] =  {
     [I2C_1] = MUTEX_INIT,
 #endif
 #if I2C_2_EN
-    [I2C_2] = MUTEX_INIT
+    [I2C_2] = MUTEX_INIT,
 #endif
 #if I2C_3_EN
-    [I2C_3] = MUTEX_INIT
+    [I2C_3] = MUTEX_INIT,
 #endif
 };
 
 int i2c_init_master(i2c_t dev, i2c_speed_t speed)
 {
-    I2C_TypeDef *i2c;
-    GPIO_TypeDef *port;
-    int pin_scl = 0, pin_sda = 0;
+    I2C_TypeDef *i2c = i2c_cfg[dev].dev;
     int ccr;
 
     /* read speed configuration */
@@ -85,27 +80,16 @@ int i2c_init_master(i2c_t dev, i2c_speed_t speed)
             return -2;
     }
 
-    /* read static device configuration */
-    switch (dev) {
-#if I2C_0_EN
-        case I2C_0:
-            i2c = I2C_0_DEV;
-            port = I2C_0_PORT;
-            pin_scl = I2C_0_SCL_PIN;
-            pin_sda = I2C_0_SDA_PIN;
-            I2C_0_CLKEN();
-            I2C_0_PORT_CLKEN();
-            NVIC_SetPriority(I2C_0_ERR_IRQ, I2C_IRQ_PRIO);
-            NVIC_EnableIRQ(I2C_0_ERR_IRQ);
-            break;
-#endif
+    i2c_poweron(dev);
 
-        default:
-            return -1;
-    }
+    /* I2C port clk enable */
+    RCC->AHBENR |= RCC_AHBENR_GPIOBEN;
+
+    NVIC_SetPriority(i2c_cfg[dev].er_irqn, I2C_IRQ_PRIO);
+    NVIC_EnableIRQ(i2c_cfg[dev].er_irqn);
 
     /* configure pins */
-    _pin_config(port, pin_scl, pin_sda);
+    _pin_config(dev, GPIOB, i2c_cfg[dev].scl_pin, i2c_cfg[dev].sda_pin);
 
     /* configure device */
     _i2c_init(i2c, ccr);
@@ -116,9 +100,9 @@ int i2c_init_master(i2c_t dev, i2c_speed_t speed)
         /* disable peripheral */
         i2c->CR1 &= ~I2C_CR1_PE;
         /* toggle both pins to reset analog filter */
-        _toggle_pins(port, pin_scl, pin_sda);
+        _toggle_pins(GPIOB, i2c_cfg[dev].scl_pin, i2c_cfg[dev].sda_pin);
         /* reset pins for alternate function */
-        _pin_config(port, pin_scl, pin_sda);
+        _pin_config(dev, GPIOB, i2c_cfg[dev].scl_pin, i2c_cfg[dev].sda_pin);
         /* make peripheral soft reset */
         i2c->CR1 |= I2C_CR1_SWRST;
         i2c->CR1 &= ~I2C_CR1_SWRST;
@@ -142,7 +126,7 @@ static void _i2c_init(I2C_TypeDef *i2c, int ccr)
     i2c->CR1 |= I2C_CR1_PE;
 }
 
-static void _pin_config(GPIO_TypeDef *port, int pin_scl, int pin_sda)
+static void _pin_config(i2c_t dev, GPIO_TypeDef *port, int pin_scl, int pin_sda)
 {
     /* Set GPIOs to AF mode */
     port->MODER &= ~(3 << (2 * pin_scl));
@@ -167,20 +151,20 @@ static void _pin_config(GPIO_TypeDef *port, int pin_scl, int pin_sda)
     /* Configure GPIOs to for the I2C alternate function */
     if (pin_scl < 8) {
         port->AFR[0] &= ~(0xf << (4 * pin_scl));
-        port->AFR[0] |= (I2C_0_SCL_AF << (4 * pin_scl));
+        port->AFR[0] |= (i2c_cfg[dev].af_scl_sda << (4 * pin_scl));
     }
     else {
         port->AFR[1] &= ~(0xf << (4 * (pin_scl - 8)));
-        port->AFR[1] |= (I2C_0_SCL_AF << (4 * (pin_scl - 8)));
+        port->AFR[1] |= (i2c_cfg[dev].af_scl_sda << (4 * (pin_scl - 8)));
     }
 
     if (pin_sda < 8) {
         port->AFR[0] &= ~(0xf << (4 * pin_sda));
-        port->AFR[0] |= (I2C_0_SDA_AF << (4 * pin_sda));
+        port->AFR[0] |= (i2c_cfg[dev].af_scl_sda << (4 * pin_sda));
     }
     else {
         port->AFR[1] &= ~(0xf << (4 * (pin_sda - 8)));
-        port->AFR[1] |= (I2C_0_SDA_AF << (4 * (pin_sda - 8)));
+        port->AFR[1] |= (i2c_cfg[dev].af_scl_sda << (4 * (pin_sda - 8)));
     }
 }
 
@@ -215,18 +199,12 @@ static void _toggle_pins(GPIO_TypeDef *port, int pin_scl, int pin_sda)
 
 int i2c_acquire(i2c_t dev)
 {
-    if (dev >= I2C_NUMOF) {
-        return -1;
-    }
     mutex_lock(&locks[dev]);
     return 0;
 }
 
 int i2c_release(i2c_t dev)
 {
-    if (dev >= I2C_NUMOF) {
-        return -1;
-    }
     mutex_unlock(&locks[dev]);
     return 0;
 }
@@ -240,18 +218,7 @@ int i2c_read_bytes(i2c_t dev, uint8_t address, char *data, int length)
 {
     unsigned int state;
     int i = 0;
-    I2C_TypeDef *i2c;
-
-    switch (dev) {
-#if I2C_0_EN
-        case I2C_0:
-            i2c = I2C_0_DEV;
-            break;
-#endif
-
-        default:
-            return -1;
-    }
+    I2C_TypeDef *i2c = i2c_cfg[dev].dev;
 
     switch (length) {
         case 1:
@@ -369,18 +336,7 @@ int i2c_read_reg(i2c_t dev, uint8_t address, uint8_t reg, char *data)
 
 int i2c_read_regs(i2c_t dev, uint8_t address, uint8_t reg, char *data, int length)
 {
-    I2C_TypeDef *i2c;
-
-    switch (dev) {
-#if I2C_0_EN
-        case I2C_0:
-            i2c = I2C_0_DEV;
-            break;
-#endif
-
-        default:
-            return -1;
-    }
+    I2C_TypeDef *i2c = i2c_cfg[dev].dev;
 
     /* send start condition and slave address */
     DEBUG("Send slave address and clear ADDR flag\n");
@@ -400,23 +356,7 @@ int i2c_write_byte(i2c_t dev, uint8_t address, char data)
 
 int i2c_write_bytes(i2c_t dev, uint8_t address, char *data, int length)
 {
-    I2C_TypeDef *i2c;
-
-    switch (dev) {
-#if I2C_0_EN
-        case I2C_0:
-            i2c = I2C_0_DEV;
-            break;
-#endif
-#if I2C_1_EN
-        case I2C_1:
-            i2c = I2C_1_DEV;
-            break;
-#endif
-
-        default:
-            return -1;
-    }
+    I2C_TypeDef *i2c = i2c_cfg[dev].dev;
 
     /* start transmission and send slave address */
     DEBUG("sending start sequence\n");
@@ -438,18 +378,7 @@ int i2c_write_reg(i2c_t dev, uint8_t address, uint8_t reg, char data)
 
 int i2c_write_regs(i2c_t dev, uint8_t address, uint8_t reg, char *data, int length)
 {
-    I2C_TypeDef *i2c;
-
-    switch (dev) {
-#if I2C_0_EN
-        case I2C_0:
-            i2c = I2C_0_DEV;
-            break;
-#endif
-
-        default:
-            return -1;
-    }
+    I2C_TypeDef *i2c = i2c_cfg[dev].dev;
 
     /* start transmission and send slave address */
     _start(i2c, address, I2C_FLAG_WRITE);
@@ -466,36 +395,13 @@ int i2c_write_regs(i2c_t dev, uint8_t address, uint8_t reg, char *data, int leng
 
 void i2c_poweron(i2c_t dev)
 {
-    switch (dev) {
-#if I2C_0_EN
-        case I2C_0:
-            I2C_0_CLKEN();
-            break;
-#endif
-#if I2C_1_EN
-        case I2C_1:
-            I2C_1_CLKEN();
-            break;
-#endif
-    }
+    RCC->APB1ENR |= i2c_cfg[dev].clk_en;
 }
 
 void i2c_poweroff(i2c_t dev)
 {
-    switch (dev) {
-#if I2C_0_EN
-        case I2C_0:
-            while (I2C_0_DEV->SR2 & I2C_SR2_BUSY);
-            I2C_0_CLKDIS();
-            break;
-#endif
-#if I2C_1_EN
-        case I2C_1:
-            while (I2C_0_DEV->SR2 & I2C_SR2_BUSY);
-            I2C_0_CLKDIS();
-            break;
-#endif
-    }
+    while (i2c_cfg[dev].dev->SR2 & I2C_SR2_BUSY);
+    RCC->APB1ENR &= ~(i2c_cfg[dev].clk_en);
 }
 
 static void _start(I2C_TypeDef *dev, uint8_t address, uint8_t rw_flag)
@@ -555,11 +461,10 @@ static inline void _stop(I2C_TypeDef *dev)
     dev->CR1 |= I2C_CR1_STOP;
 }
 
-#if I2C_0_EN
 void I2C_0_ERR_ISR(void)
 {
-    unsigned state = I2C_0_DEV->SR1;
-    DEBUG("\n\n### I2C ERROR OCCURED ###\n");
+    unsigned state = I2C1->SR1;
+    DEBUG("\n\n### I2C_0 ERROR OCCURED ###\n");
     DEBUG("status: %08x\n", state);
     if (state & I2C_SR1_OVR) {
         DEBUG("OVR\n");
@@ -584,6 +489,32 @@ void I2C_0_ERR_ISR(void)
     }
     while (1);
 }
-#endif /* I2C_0_EN */
 
-#endif /* I2C_NUMOF */
+void I2C_1_ERR_ISR(void)
+{
+    unsigned state = I2C2->SR1;
+    DEBUG("\n\n### I2C_1 ERROR OCCURED ###\n");
+    DEBUG("status: %08x\n", state);
+    if (state & I2C_SR1_OVR) {
+        DEBUG("OVR\n");
+    }
+    if (state & I2C_SR1_AF) {
+        DEBUG("AF\n");
+    }
+    if (state & I2C_SR1_ARLO) {
+        DEBUG("ARLO\n");
+    }
+    if (state & I2C_SR1_BERR) {
+        DEBUG("BERR\n");
+    }
+    if (state & I2C_SR1_PECERR) {
+        DEBUG("PECERR\n");
+    }
+    if (state & I2C_SR1_TIMEOUT) {
+        DEBUG("TIMEOUT\n");
+    }
+    if (state & I2C_SR1_SMBALERT) {
+        DEBUG("SMBALERT\n");
+    }
+    while (1);
+}